By Guy F. Webster, Anthony V. Rawlings
Addressing probably the most regularly encountered stipulations noticeable by way of the dermatologist, this resource analyzes the pathophysiology, review, analysis, scientific gains, and keep watch over of zits. With full-color illustrations, this resource delves into the to be had remedies for tricky circumstances of zits and scarring and offers professional discussions of administration regimens together with topical and systemic remedies, laser remedies, and new drugs.
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Additional info for Acne and its therapy
In terminal follicles of rats, loricrin is found predominantly in the upper duct (48). The lumen of the duct provides a suitable environment for bacterial colonization, but recently it has been demonstrated that the keratinocytes of follicles are a source of antimicrobial peptides called defensins (49). Structure of the Pilosebaceous Gland All sebaceous glands are similar in structure. They consist of either a single lobule (acinus) or a collection of acini. The glands are separated from the dermis by a connective tissue capsule, consisting of fine collagen fibers, fibroblasts, and a capillary plexus.
Dermatology 2003; 204(1):17– 22. 61. Zouboulis CC, Boschnakow A. Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol 2001; 26(7):600– 607. 62. Thiele JJ, Weber SU, Packer L. Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J Invest Dermatol 1998; 113:390– 395. 63. Fluhr JW, Man M-Q, Brown BE, et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol 2003; 120: 728 – 737.
Am J Med 1995; 16(suppl):80 – 88. 93. Imperato-McGinley J, Gautier T, Cai LQ, Yee B, Epstein J, Pochi P. The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 1993; 76:524– 528. 94. Holland DB, Cunliffe WJ, Norris JFB. Differential response if sebaceous glands to exogenous testosterone. Br J Dermatol 1998; 139:102– 103. 95. Henderson CA, Knaggs H, Clark A, Highet AS, Cunliffe WJ. Apert’s syndrome and androgen receptor staining of the basal cells of sebaceous glands.