By D. P. Griswold Jr., W. R. Laster Jr., M. W. Trader, D. J. Dykes (auth.), Professor Dr. Hans-Jörg Senn (eds.)
H.-J. Senn Adjuvant Chemotherapy (ACT) of breast melanoma has now emerged as one of many arguable su):>jects in medical and likewise experimental oncology. pushed by means of transforming into frustration approximately stagnating treatment charges in breast melanoma [1,4] and encouraged via dependent demonstration of hugely healing results of adjuvant systemic remedy in animal types [6, eleven] and in different formative years neoplasias , researchers brought ACT to the first therapy of breast melanoma with nice desire a few 15 years in the past. After a primary wave of remoted "historic" trials with mostly constrained yet in a single case outstanding luck [5, 9], a moment new release of ACT reviews used to be initiated through NSABP investigators and oncology facilities in Europe [2, 6, 13]. those trials have been good performed statistically and diagnostically, and all within the early Seventies incorporated a surgical keep an eye on arm. Early and intermediate valuable results on relapse-free survival (RFS) after 2-3 years median commentary time then caused an entire sequence of ACT reports in breast melanoma. those "third-gener ation" stories often looked a few confident effect of ACT as a given truth, losing surgical keep an eye on regimens and evaluating various ACT regimens, with a bit of luck in a potential, randomized approach 1984 Fig. 1. The mushrooming of adjuvant reports in breast melanoma XII creation [reviews in three, 14]. The "mushrooming" of ACT reports in breast melanoma over the past 10 and particularly five years is proven in Fig. 1, and it will get particularly bulky even for the insider to maintain on best of the multitude of occasionally conflicting data.
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Additional info for Adjuvant Chemotherapy of Breast Cancer: Papers Presented at the 2nd International Conference on Adjuvant Chemotherapy of Breast Cancer, Kantonsspital St. Gallen, Switzerland, March 1 – 3, 1984
Waring MJ (1981) DNA modification and cancer. Ann Rev Biochem 50: 159-192 109. Weichselbaum RR, Schmidt A, Little JB (1982) Cellular repair factors influencing radiocurability of human malignant tumours. Br J Cancer 45: 10-16 110. Wiestler 0, Kleihues P, Pegg AE (1984) 06- alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis 5: 121-124 111. Woodcock DM, Cooper IA (1981) Evidence for double replication of chromosomal DNA segments as a general consequence of DNA replication inhibition.
9%. The patients were treated at many hospitals and by various procedures. Nodal status is known for 2,765 of the breast carcinoma patients; 576 patients did not have nodes examined, and there is no information on 216. Of all the BCDDP-detected carcinomas whose lymph node status is known, 2,066 (75%) had negative lymph nodes (see Table 1). This is a number much smaller than that usually seen in unscreened populations . 5%) invasive carcinomas of less than 1 cm in diameter have positive axillary lymph nodes.
65, 74, 75]). We would expect this cell type-dependent capability to remove 06-alkyldGuo to be reflected by similar intertumor variations, if the respective "06-alkyldGuo repair-phenotypes" of the normal cells of origin were retained in the cells through the multistep process of malignant transformation and remain stably expressed in the tumor cells. Note, however, that neither the range of variation of DNA repair capacity for different types of DNA adducts is wellestablished for the individual cells of normal tissues, nor has this range been sufficiently well defined with respect to interindividual variability within human populations [56, 61, 87, 100].