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The forefront technological know-how awarded at this symposium represents the easiest of foreign pharmaceutics, polymer technological know-how, biotechnology, molecular biology and telephone biology learn efforts. The publication emphasises the next parts of drug supply examine: more desirable equipment of healing management, particularly for proteins and peptides; novel supply platforms; complicated provider and concentrating on structures; and new healing suggestions and service, receptor and mobile interactions and mechanisms for healing purposes
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Extra info for Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993
Recently, the IPEC technique was used for re ceptor-mediated delivery of antisence oligonucleotide into cells . In this work, the com plex of a transferrin-poly( L-ly sine) conjugate with antisense oligonucleotide to c-rnyb-encoding DNA was shown to specifically inhibit hu man leukaemia HL-60 cell proliferation. The in hibitory effect of this IPEC was significantly stronger than that of free oligonucleotide. The most impressive achievement obtained using DNA IPECs was their application for tar geted gene delivery in vivo.
Martinek, Chemical modification of proteins (enzymes) with water-insoluble reagents, Dokl. Acad. Nauk SSSR, Ser. Biockhim. (in Russian) 278 (1984) 246-248 (English translation (1985) 295-297). V. L. P. Torchilin, K. V. Levashov, Efficiency of protein amino group acylation with fatty acid chlorides in reversed mi celles of Aerosol OT in octane, Bioorganich. Khimiya (in Russian), 13 (1987) 1321-1324. N. L. V. P. V. Levashov and K. Martinek, Phospholipids covalent binding with proteins in the system of reverse micelles, Bioorganich.
A. B. E. ) Soviet Sei. , B. Chemistry, Harwood Academic Publish ers, New York, 1984, Vol. 4, pp. 207-282. V. V. L. F. l. S. A. Kabanov, DNA interpolyelectrolyte complexes as a tool for effi cient cell transformation, Biopolymers, 31, (1991) 1437-1443. A. B. A. Kabanov, The equilibrium of interpolyelectrolyte reactions and the phenomenon of molecular recognition in the solutions of interpolyelectrolyte complexes, Uspekhi Khim. (in Russian), 60 (1991) 1570-1595. E. Wagner, M. Cotten, R. L. Birnsteil, Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells, Proc.