Download Annual Reports in Medicinal Chemistry, 6 by C K Cain PDF

By C K Cain

ANNUAL reviews IN MED CHEMISTRY V6 PPR.

Show description

Read or Download Annual Reports in Medicinal Chemistry, 6 PDF

Similar nonfiction_12 books

Surface Modification Technologies XIII: Proceedings of a conference held in Singapore, 7-10 October 1999

The forty six papers offered at this occasion conceal challenging fabrics, Lasers and floor Melting, Electrodeposition and evaluate of converted Surfaces, Thermal Spray recommendations, Nitride Coatings and overview of changed Surfaces.

Extra resources for Annual Reports in Medicinal Chemistry, 6

Sample text

Thus Scatton50 concluded t h a t amantadfne may s t i m u l a t e dopamine s y n t h e s i s and Stromberg5l has reported compatible data. It: i s too early t o assess the relevance of t h i s finding t o the clinical efficacy of amantadine Does amantadine block the reuptake of catecholamines and i s t h i s 48 - Sect, I - CNS Agents Engelhardt, Ed. e f f e c t r e l a t e d t o i t s a n t i p a r k i n s o n a c t i o n ? S e v e r a l groups have s t u d i e d the e f f e c t of amantadine upon catecholamine uptake s i n c e Vernier47 r e p o r t e d d a t a compatible w i t h r e u p t a k e blockade.

Lewis and M. Readhead, g . ,2,525 (1970). 10. J. Villarreal and M. Seevers, Addendum to the minutes of the 32nd Meeting of the Committee on Problems of Drug Dependence, Nat. Acad. , 1970. 11. I. Seki and H. Takagi, Chem. Pharm. , 1104 (1970). 12. T. Kametani, K. Kigasawa, H. Hiiragi, N. Wagatsuma, K. Wakisaka, F. Satoh and S. Saito, J. Med. , Q, 1064 (1970). 13. E. May and M. Takeda, J. Med. , 2, 805 (1970). 14. M. Takeda and E. May, -*,ibid 13, 1223 (1970). 18, Chap. 4 Analgesics 41 - Robinson 15.

Table 1 l i s t s f i v e mechanisms by which amantadine and other drugs could counteract the d e f i c i t of extrapyramidal i n h i b i t i o n which is respons i b l e f o r symptoms of parkinsonism. Recent evidence points t o a l o c a l r e l e a s e of catecholamines as the major mode of a c t i o n of amantadine i n parkinsonism. This i s the most s e n s i t i v e e f f e c t of amantadine reported t o date and occurs a t the lowest dose. 88 c l a r i f i e d t h i s point. They reported t h a t a small trans i e n t pressor e f f e c t of amantadine alone, intravenously i n dogs, was markedly i n t e n s i f i e d b dopamine-priming.

Download PDF sample

Rated 4.58 of 5 – based on 30 votes