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By Thomas Bieber, Donald Y. M. Leung

This reference explores the epidemiology, etiology, administration, and pathophysiological mechanisms of atopic dermatitis and identifies strength genetic and environmental elements linked to allergic epidermis immune responses-compiling the newest examine, diagnostic strategies, and healing techniques for the prevention, regulate, and remedy of this power inflammatory affliction. Written by way of top specialists within the box, Atopic Dermatitis addresses ·the medical gains of atopic dermatitis (AD) ·the function of antigen-presenting cells, T-cells, and keratinocytes in pathogenesis ·food hypersensitive reaction and infections in teenagers ·the id and removal of exacerbating parts ·emerging anti inflammatory brokers for controlling advert ·the significance of animal versions ·the influence of advert at the emotional improvement of sufferers Discussing the mounting occurrence of dermis disorder, in addition to its social and fiscal effect, Atopic Dermatitis is a definitive and crucial advisor for dermatologists, allergists, immunologists, pharmaceutical and beauty chemists, internists, pediatricians, epidemiologists, and graduate and clinical institution scholars in those disciplines.

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Nature 402:B18-23,1999. Q Hamid, M Boguniewicz, DY Leung. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870-876, 1994. A Trautmann, M Akdis, D Kleemann, F Altznauer, HU Simon, T Graeve, M Noll, EB Brocker, K Blaser, CA Akdis. T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest 106: 25-35, 2000. C Bruijnzeel-Koomen, E Storz, G Menz, P Bruijnzeel. Skin eosinophilia in patients with allergic and nonallergic asthma and atopic dermatitis.

Pediatr Allergy Immunol 9: 116-124, 1998. B WUthrich. Clinical aspects, epidemiology, and prognosis of atopic dermatitis. Ann Allergy Asthma Immunol 83:464-470, 1999. C Walker, MK Kagi, P Ingold, P Braun, K Blaser, B WUthrich. Atopic dennatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity. Clin Exp Allergy 23:45-153, 1993. MK Kagi, B WUthrich, E Montano, J Barandun, K Blaser, C Walker. Differential cytokine profiles in peripheral blood lymphocyte supernatants and skin biopsies from patients with different fonns of atopic dermatitis, psoriasis and nonnal individuals.

Atopic dermatitis usually begins in infancy when it may be confused with seborrheic dennatitis (69). However, the former usually clears in the first year of life, whereas atopic dermatitis is characterized by a more chronic relapsing and remitting course. The distribution of atopic dennatitis may change early in life, from involvement of the scalp and face to involvement of the neck and flexures between 1 and 2 years of age (70). Age of onset in community cases of atopic eczema may be later than that reported in hospital-based studies.

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