By Neil S. Sadick, Mary Lupo, Diane S. Berson, Zoe Diana Draelos
Cosmeceuticals are skin-care items that fall among a beauty and a pharmaceutical; that's, they've got energetic materials that counter pores and skin getting older and advertise pores and skin rejuvenation. As such, they're a useful adjunct to the beauty dermatologist or plastic medical professional acting minimally invasive aesthetic systems. a lot of those items were built in Europe and are just now being brought to america, so this consultant from specialist practitioners explains how top to combine the potential for cosmeceutical items into the simplest overseas scientific perform.
Read or Download Cosmeceutical Science in Clinical Practice (Series in Cosmetic and Laser Therapy) PDF
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Extra resources for Cosmeceutical Science in Clinical Practice (Series in Cosmetic and Laser Therapy)
Growth Factors Secreting Stem Cells Adipose-derived stem cells, a population of pluripotent cells, have been studied for promotion of wound healing by virtue of their ability to secrete growth factors. 3 Synthetic Growth Factors Registered as Cosmetic Ingredients INCI name Growth factor Human oligopeptide-1 Human oligopeptide-2 Human oligopeptide-3 Human oligopeptide-5 Human oligopeptide-7 Human oligopeptide-8 Human oligopeptide-10 Human oligopeptide-11 Human oligopeptide-12 Human oligopeptide-13 Human oligopeptide-14 Human oligopeptide-15 Human oligopeptide-19 Human oligopeptide-20 Epidermal growth factor Insulin-like growth factor-1 Basic fibroblast growth factor Keratinocyte growth factor Transforming growth factor beta-3 Interleukin 10 Platelet derived growth factor Vascular endothelial growth factor Fibroblast growth factor 10 Acidic fibroblast growth factor Transforming growth factor alpha Interleukin 4 Nerve growth factor Tissue inhibitor of metalloproteinases Source: From Ref.
12. Mansbridge J, Liu K, Patch R, et al. Three-dimensional fibroblast culture implant for the treatment of diabetic foot ulcers: metabolic activity and therapeutic range. Tissue Eng 1998; 4: 403–14. 13. Schütte H, Kula MR. Pilot- and process-scale techniques for cell disruption. Biotechnol Appl Biochem. 1990; 12: 599–620. 14. Park BS, Jang KA, Sung JH, et al. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008; 34: 1323–6. 15. Gottscha TE, Bailey JE, Cosmetic, Toiletry and Fragrance Association.
AP-1 stimulates transcription of matrix metalloproteinase (MMP) growth factor genes in fibroblasts and keratinocytes, and inhibits type 1 procollagen gene expression in fibroblasts (5). Multiple studies have shown that increased secretion of MMPs resulting from intrinsic and extrinsic aging results in breakdown of the dermal matrix (6). MMP-1 (collagenase) produces cleavage at a single site in central triple helix of fibrillar type I and type III collagen. The cleaved subunits are further degraded by MMP-3 (stromelysine 1) and MMP-9 (gelatinase).