By David C. Aron (auth.), Brooke Swearingen, Beverly M. K. Biller (eds.)
In Cushing’s affliction, major professionals within the box provide an intensive assessment of the pathogenesis, diagnostic set of rules and healing procedures for this advanced affliction. starting with a desirable heritage of Cushing's sickness that outlines its old value to either endocrinology and neurosurgery, the ebook is going onto to hide the entire diversity of vital concerns, together with the molecular pathogenesis of Cushing’s, anatomic pathology, the analysis of Cushing's syndrome, the differential of pseudo-Cushing's syndromes, hypercortisolemia, surgical removing of the corticotroph adenoma, post-operative administration and review of remission, radiotherapeutic concepts, and the fascinating advancements in clinical remedy. additionally, the booklet additionally addresses Cushing's sickness within the pediatric inhabitants, provided that its medical manifestations and influence on development should be serious; silent corticotroph adenomas as a special medical entity; analysis and administration of Cushing's ailment while pregnant, bilateral adrenalectomy, and, eventually, the long term mental manifestations of hypercortisolemia. accomplished and a useful addition the literature, Cushing’s sickness is a vital reference for boosting analysis and remedy of this debilitating disorder.
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Extra resources for Cushing's Disease
The cells in Crooke’s adenomas resemble the cells with Crooke’s hyaline change seen in normal corticotrophs as a response to excess glucocorticoids from exogenous or endogenous sources. 1d–f). Ultrastructurally, most functioning corticotroph adenoma cells resemble normal corticotroph cells. The cells have an oval to polygonal shape with eccentric large, polygonal to ovoid nuclei. The cytoplasm contains moderately developed Golgi and rough endoplasmic reticulum (RER). Perinuclear bundles of intermediate filaments of cytokeratin are characteristic.
Lamberts SW et al. The mechanism of the suppressive action of bromocriptine on adrenocorticotropin secretion in patients with Cushing’s disease and Nelson’s syndrome. J Clin Endocrinol Metab. 1980;51:307–11. Lamberts SW et al. Failure of clinical remission after transsphenoidal removal of a microadenoma in a patient with Cushing’s disease: multiple hyperplastic and adenomatous cell nets in surrounding pituitary tissue. J Clin Endocrinol Metab. 1980;50:793–5. 37. Kovacs K. The pathology of Cushing’s disease.
Verges B et al. Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study. J Clin Endocrinol Metab. 2002;87:457–65. 53. Asa SL, Somers K, Ezzat S. The MEN-1 gene is rarely down-regulated in pituitary adenomas. J Clin Endocrinol Metab. 1998;83:3210–2. 54. Satta MA et al. Expression of menin gene mRNA in pituitary tumours. Eur J Endocrinol. 1999;140:358–61. 55. Pellegata NS et al. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.