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By Ramon L. Sanchez

Univ. of Texas, Galveston. instruction manual and primer in dermatopathology for citizens of pathology and dermatology, and clinical scholars. such a lot entries contain scientific, histology, and different details. Illustrated in halftone. Wire-spiral binding. DNLM: dermis Diseases--pathology.

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Mogeneous cytoplasm. Frequently one observes on the floor of the bullae irregular upward growth of papillae that are lined by a single row of basal cells referred to as villi. Immunofluorescence Testing In direct immunofluorescence testing of the skin in patients with pemphigus vulgaris, unfixed frozen sections of perilesional skin are used. Fluorescein labeled antihuman, IgG, IgA, IgM, C3 and C4 are applied to various sections. With positive tests there is fluorescence of the intercellular spaces of the epidermis (chicken wire) (Fig.

Epidermodysplasia verruciformis (HPV-5, 8, 12, 14, 15 and 17) presents as extensive erythematous scaly macules or papules and seems to be associated with an autosomal recessive defect in cell mediated immunity. There is an increased incidence of skin cancer in long term lesions of epidermodysplasia verruciformis, especially in sun-exposed areas. Histology Verrucae vulgaris are characterized by compact type hyperkeratosis, acanthosis and papillomatosis. There are tiers of parakeratosis over the tips of the dermal papillae, as well as hypergranulosis and foci of koilocytotic cells (Fig.

CHAPTER 1 CHAPTER 3 Papillomatosis, Atrophy and Alterations of the Granular Layer Gayle S. Westhoven Section 4. Papillomatosis Papillomatosis results from the upward proliferation of dermal papillae causing the epidermis to be undulated. It results in a “warty” clinical appearance. It is often accompanied by hyperkeratosis, parakeratosis and acanthosis, but the hallmark of papillomatosis is the upward projections of the epidermis. Verruca/Epidermodysplasia Verruciformis Clinical Verrucae present in a variety of clinical patterns, all caused by subtypes of the human papillomavirus (HPV), including verruca vulgaris (HPV-4, 7), palmoplantar wart (HPV-1 and -2), verruca plana (HPV-3), and condyloma acuminatum (HPV-6, 11, 16, and 18).

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