Download Embryonic Stem ­Cells - Recent ­Advances in Plu­ripotent by Craig S. Atwood PDF

By Craig S. Atwood

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Extra info for Embryonic Stem ­Cells - Recent ­Advances in Plu­ripotent Stem C­ell-Based Regen­erative Medicin­e

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In: Caplan 1992, 3-8 Luna, F. (1997). Vulnerable populations and morally tainted experiments. Bioethics 11, 256264 Segal, N. L. (1992). Twin research at Auschwitz-Birkenau. Implications for the use of Nazi data today. In: Caplan 1992, 281-299 Singer P. (1993). Practical ethics, 2nd edn. Cambridge University Press, Cambridge Vawter, D. ; K. G. Gervais; W. Kearne; A. L. Caplan (1991): Fetal tissue transplantation and the problem of elective abortion. In: W. Land; J. ). Organ replacement therapy: Ethics, justice and commerce.

Moreover some kind of promoter allowed a continued transgene expression that increases the efficiency of iPSC generation but on the other side severely impairs iPSCs differentiation both in vivo and in vitro [Sommer CA et al 2010]. Spontaneous transgene reactivation may also occur and lead to tumor formation [Okita K et al 2007]. Partial reprogramming may have arisen from cells that either did not receive all reprogramming factors or expressed the factors with stochiometries or expression levels that did not allow for complete reprogramming.

Also karyotypic abnormalities, might be at least partially dependent on culture techniques [Mitalipova et al. 2005]. Accordingly hESCs must be produced under current Good Manufacturing Practices (cGMP) quality. That is defined by both the European Medicines Agency and the Food and Drug Administration, as a requirement for clinical-grade cells, offering optimal defined quality and safety in cell transplantation. In Europe, the requirement for cell therapy products is outlined in several directives and guidelines that are pertinent as regards hESCs (Directive 2004/23/EC, Commission Directives 2006/17/EC and 2006/86/EC).

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