By E. Tur, P. Itin, G.B.E. Jemec
Lately, new applied sciences to enquire dermis reaction have allowed researchers to discover the interaction of environmental and genomic parts in epidermis phone biology, decipher the biochemical steps undertaken within the method, and research the genetics underlying diversifications in pores and skin reaction to the surroundings. during this quantity the cutting-edge findings, starting from molecular biology to epidemiology, are mentioned completely. The ebook therefore offers new insights for dermatologists, allergologists and immunologists who search a greater figuring out of sickness tactics and new healing options.
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Extra resources for Environmental Factors in Skin Disease
In mice, the agouti protein antagonizes the effects of MC1R . The function of agouti in humans is poorly understood. Changes in MC1R expression have been shown to confer a significant risk for all UV-induced skin cancers [64, 67, 68]. This effect remains significant, even after adjustment for skin color, indicating that MC1R may play a role in carcinogenesis that is not related to its effect on skin pigmentation, possibly by influencing the inflammatory response to UV irradiation . A few other genetic alterations have been linked to the development of UVassociated skin cancer.
Madronich S, McKenzie RL, Bjorn LO, Caldwell MM: Changes in biologically active ultraviolet radiation reaching the Earth’s surface. J Photochem Photobiol B 1998;46:5–19. Norval M, Cullen AP, de Gruijl FR, Longstreth J, Takizawa Y, Lucas RM, Noonan FP, van der Leun JC: The effects on human health from stratospheric ozone depletion and its interactions with climate change. Photochem Photobiol Sci 2007;6:232–251. Walker SL, Hawk JLM, Young AR: Acute and chronic effects of ultraviolet radiation on the skin; in Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz S (eds): Fitzpatrick’s Dermatology in General Medicine, ed 6.
A most notable example is the Li-Fraumeni syndrome (MIM151623), caused by mutations in TP53, and characterized by an increase in the frequency of sarcomas, melanomas and hematological tumors, but not by an elevated rate of SCCs [46, 47]. Conversely, polymorphisms in the XPD gene have been shown to modify melanoma risk in subjects with specific host characteristics, such as older age, lack of dysplastic naevi or low tanning ability . Hereditary Syndromes Predominantly Associated with Malignant Melanoma As for BCCs and SCCs, UV light plays an important role in the pathogenesis of MMs .