Download Progress in Brain Research Volume 29 Brain Barrier Systems by Ábel Lajtha PDF

By Ábel Lajtha

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Extra info for Progress in Brain Research Volume 29 Brain Barrier Systems

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Thus, it seems to me that in this abnormal condition one has a difference in the behavior of the glucose exchange mechanisms between the blood and the brain on the one hand, and between the blood and CSF on the other. Perhaps somebody will have a comment on that? G. PAPPAS: I think this is a rather important aspect. If I might summarize in general: ifyou introduced marker particles into the CSF fluid, the uptake by the choroideal plexus epithelium is via pinocytotic vesicles or vacuoles at the base of the villi.

CSAKY: May I point out again that indeed we have to distinguish between the transport of sugar from the capillary into the brain and the sugar exchange between the blood and CSF. When I talked about the choroid plexus I referred to the latter, while the blood-to-brain transport, I believe, is mediated through the glia cells. The two systems are different morphologically and most likely also functionally. One is an epithelial transport mechanism, the other is the glial transport. While we have some limited idea about the epithelium we are in the dark about the transport in the glia.

BRIGHTMAN: 1 would very much like to find them, but as far as visualizing them, we are limited. D. M . WOODBURY: So you cannot really make any conclusions about these smaller molecules? M. BRIGHTMAN: NO. K. A. C. ELLIOTT: 1 wondered if Dr. Brightman could straighten me out a little bit: Sometimes you spoke about these particles as though they were just large, inert particles; sometimes you indicated that they were proteins. Now if I am right, they were both proteins and I wonder how this would affect reactions within the tissue.

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